Next up for Halep is another 19-year-old youngster, Iga Swiatek of Poland, whom Halep defeated in the round of 16 here last year.
The last set became a lop-sided affair for Tianjin, which went on a 12-4 run to pull away and kept the advantage until the end.
The Schalke coach promised to find a way to develop strategies to revitalize his players' confidence.
"We showed our character," Jiangsu coach Ding Tie said. "But after some young players substituted in, the level of our defense went down."
In the other action on Friday, women's third seed Elina Svitolina cruised past 27th-seeded Ekaterina Alexandrova 6-4, 7-5 to advance to the next round. Argentine qualifier Nadia Podoroska extended her stunning run on clay after the restart of the season, as the 23-year-old dispatched Anna Karolina Schmiedlova 6-3, 6-2 to become the first Argentinean women's player to reach the fourth round in Paris since 2011. Enditem
Everton playmaker James Rodriguez and Galatasaray striker Radamel Falcao will return to the international fold for Colombia's qualifiers against Venezuela and Chile.
"The match today I think we both play really well and a really great match. She played unbelievably good," said Zhang, who defeated Burel 6-3, 7-6(3) in the Strasbourg Open before coming to Paris.
The first 45 minutes were entertaining, but after the break Barca began to look fatigued. Ronald Koeman made several changes, bringing Francisco Trincao, Pedri and Miralem Pjanic into the action, while Sergino Dest made his debut for the injured Jordi Alba. Despite Trincao having a late shot saved, Barca didn't do enough to win, while Sevilla looked happy with a point.
The injury was confirmed shortly after Spain coach Luis Enrique had named the defender in his squad to play Portugal, Switzerland and Ukraine in the coming days.
Leipzig remained offensively minded but for all that Julian Nagelsmann's men squandered a number of chances as neither Dani Olmo nor Nordi Mukiele was able to extend the lead.
The 2020-21 season will be played behind closed doors in a bubble, with all participants undergoing isolated management to ensure their safety.